1. 毕业设计（论文）的内容和要求

水凝胶生物粘合剂可以用于模拟细胞外基质的组成和物理化学性质，并已成为伤口手术缝线闭合的替代品。

然而，目前的水凝胶粘合剂往往具有较差的力学性能，较低的组织粘附能力，以及缺乏抗菌等性能。

本课题拟研发一种具有广谱抗菌活性的新型可喷涂水凝胶粘合剂，用于促进伤口愈合。

2. 参考文献

[1] A. Abbott, Cell culture: biology#8217;s new dimension, Nature 424 (2003) 870#8211;872. [2] H. Page, P. Flood, E. Reynaud, Three-dimensional tissue cultures: current trends and beyond, Cell Tissue Res. 352 (2013) 123#8211;131. [3] L.L. Ouyang, R. Yao, X. Chen, J. Na, W. Sun, 3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions, Biofabrication 7 (2015) 015010. [4] F. Pampaloni, E.G. Reynaud, E.H.K. Stelzer, The third dimension bridges the gap between cell culture and live tissue, Nat. Rev. Mol. Cell. Biol. 8 (2007) 839#8211;845. [5] P. DelNero, M. Lane, S.S. Verbridge, B. Kwee, P. Kermani, B. Hempstead, A. Stroock, C. Fischbach, 3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways, Biomaterials 55 (2015) 110#8211;118. [6] X. Xu, M.C. Farach-Carson, X. Jia, Three-dimensional in vitro tumor models for cancer research and drug evaluation, Biotechnol. Adv. 32 (2014) 1256#8211;1268. [7] G. Su, Y. Zhao, J. Wei, J. Han, L. Chen, Z. Xiao, B. Chen, J. Dai, The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties, Biomaterials 34 (2013) 3215#8211;3222. [8] Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design vari-ables and applications. Biomaterials 2003;24:4337#8211;51. [9] Cosgriff-Hernandez E, Mikos AG. New biomaterials as scaffolds for tissue engineering. Pharm Res 2008;25:2345#8211;7

3. 毕业设计（论文）进程安排

1. 2017.12-2018.1 文献调研及路线设计； 2. 2018.2-2018.6 实验合成及工艺路线优化； 3. 2018.6 数据整理及论文写作。