1. 毕业设计（论文）的内容和要求

1. 理解抑郁症的相关概念以及经鼻给药途径，明确其研究进展； 2. 熟悉经鼻给药生物材料的分类、特性； 3. 了解经鼻给药生物材料应用于治疗抑郁症的优势和缺陷； 4. 掌握基于肽类树形分子制备经鼻给药生物材料的基本方法以及表征手段。

2. 参考文献

1. Belmaker, R. H.; Agam, G., Major depressive disorder. N Engl J Med 2008, 358 (1), 55-68. 2. Erdo, F.; Bors, L. A.; Farkas, D.; Bajza, A.; Gizurarson, S., Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Res Bull 2018, 143, 155-170. 3. Kozlovskaya, L.; Abou-Kaoud, M.; Stepensky, D., Quantitative analysis of drug delivery to the brain via nasal route. J Control Release 2014, 189, 133-40. 4. Mangraviti, A.; Gullotti, D.; Tyler, B.; Brem, H., Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies. J Control Release 2016, 240, 443-453. 5. Medina, D. X.; Householder, K. T.; Ceton, R.; Kovalik, T.; Heffernan, J. M.; Shankar, R. V.; Bowser, R. P.; Wechsler-Reya, R. J.; Sirianni, R. W., Optical barcoding of PLGA for multispectral analysis of nanoparticle fate in vivo. J Control Release 2017, 253, 172-182 6. Zhang, F.; Lin, Y. A.; Kannan, S.; Kannan, R. M., Targeting specific cells in the brain with nanomedicines for CNS therapies. J Control Release 2016, 240, 212-226. 7. Zhao, Y. Z.; Lin, M.; Lin, Q.; Yang, W.; Yu, X. C.; Tian, F. R.; Mao, K. L.; Yang, J. J.; Lu, C. T.; Wong, H. L., Intranasal delivery of bFGF with nanoliposomes enhances in vivo neuroprotection and neural injury recovery in a rodent stroke model. J Control Release 2016, 224, 165-175.

3. 毕业设计（论文）进程安排

2018.12-2019.01进行文献调研，确定研究方案，完成开题报告。

2019.02-2018.04 开展实验研究，完成可跨血脑屏障生物材料的制备及相关表征。

2019.05-2019.06 进行数据汇总、整理、分析，完成毕业论文撰写和答辩相关材料准备工作。