1. 毕业设计（论文）的内容和要求

肽类树状大分子结构的规整性和高度支化、良好的生物相容性使其在免疫诊断试剂、药物基因载体、分子影像方面等生物医学领域具有非常广泛的运用。

本项目旨在设计和合成笼状硅氧烷核肽类树状大分子，建立成熟的产物合成、纯化及表征方法。

2. 参考文献

[1] Svenson, S., Tomalia, D. A. Dendrimers in biomedical applications#8212;reflections on the field. Adv. Drug Deliver. Rev. 2012, 64, 102-115. [2] Grayson, S. M., Frechet, J. M. Convergent dendrons and dendrimers: from synthesis to applications. Chem. Rev. 2001, 101, 3819-3868. [3] Lee, C. C., MacKay, J. A., Fr#233;chet, J. M., Szoka, F. C. Designing dendrimers for biological applications. Nat. Biotechnol. 2005, 23 1517-1526. [4] Xu, X., Jian, Y., Li, Y., Zhang, X., Tu, Z., Gu, Z. Bio-inspired supramolecular hybrid dendrimers self-Assembled from low-generation peptide dendrons for highly efficient gene delivery and biological tracking. ACS Nano 2014, 8, 9255-9264. [5] Zhang, Z., Zhang, X., Xu, X., Li, Y., Li, Y., Zhong, D., He Y., Gu, Z. Virus-inspired mimics based on dendritic lipopeptides for efficient tumor-specific infection and systemic drug delivery. Adv. Funct. Mater. 2015, 25, 5250-5260. [6] Zhang, X., Zhang, Z., Xu, X., Li, Y., Li, Y., Jian, Y., Gu, Z. Bioinspired therapeutic dendrimers as efficient peptide drugs based on supramolecular interactions for tumor inhibition. Angew. Chem. Int. Ed. 2015, 54, 4289-4294.

3. 毕业设计（论文）进程安排

2-3月：文献肽类树状大分子相关文献，了解肽类树状大分子发展现状，并翻译1篇外文文献； 4月：合成肽类树状大分子、对其进行结构表征； 5月：撰写毕业论文、参加毕业答辩。