1. 毕业设计（论文）的内容和要求

论文内容： d-木糖酸脱水酶，系统命名是d-木糖酸氢-裂解酶，催化木糖酸脱水反应。

木糖酸脱水酶有不同的菌株来源，比如嗜盐的古细菌富盐菌、新月丙杆菌和假单胞菌[1,2]。

不同来源的 d-木糖酸脱水酶可以利用不同的底物，比如 d-葡萄糖酸、d-木糖酸和d-木糖[3,4]。

2. 参考文献

[1] Niu W, Molefe M N, Frost J W. Microbial synthesis of the energetic material precursor 1,2,4-butanetriol.[J]. Journal of the American Chemical Society, 2003, 125(43):12998. [2] Sato T, Aoyagi S, Kibayashi C. Enantioselective total synthesis of ( )-azimine and ( )-carpaine.[J]. Cheminform, 2006, 35(8):3839. [3] Xu Y, Qian L, Pontsler A V, McIntyre T M, Prestwich GD. Synthesisof difluoromethyl substituted lysophosphatidic acid analogues [J].Tetrahedron, 2004, 60 (1): 43-49. [4] Yamada-Onodera K, Norimoto A, Kawada N, et al. Production of optically active 1,2,4-butanetriol from corresponding racemate by Microbial stereoinversion.[J]. Journal of Bioscience Bioengineering, 2007, 103(5):494-496. [5]Williamson M. U.S. biobased products market potential and projections through 2025[M]. Nova Science Publishers, 2010. [6] Luo S, Tan H, Zhang J. Thermal Degradation Characteristics of Co-Polyether (EO-THF) and the Poly (ether-urethane-urea) Cured by N-100[J]. Journal of Beijing Institute of Technology, 1995. [7] Ren T, Liu D. Synthesis of cationic lipids from 1,2,4-butanetriol[J]. Tetrahedron Letters, 1999, 40(2):209-212. [8] Wei Z, Lan H Q, Zheng J F, et al. New and Concise Approach to (R)-Lipoic Acid[J]. Synthetic Communications, 2009, 39(39):691-701.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 2018.12.12-12.18 选题，与导师讨论题目 2018.12.19 导师下达任务书 2018.12.20-2019.1.10 根据任务书要求，查找相关文献资料 2019.01.11-2019.01.23 提交开题报告 2019.01.23-05.23 完成试验并提交论文第一稿 2019.05.24-05.27 根据导师意见修改论文第一稿，完成并提交第二稿 2019.05.28-06.1 根据导师意见修改论文第二稿，完成并提交第三稿 2019.06.1-06.7 完成论文的审阅，准备答辩