复方氨氯地平阿托伐他汀钙片含量方法学研究毕业论文
2022-05-18 08:05
论文总字数:15131字
摘 要
氨氯地平阿托伐他汀钙片,适应症为多达一®(氨氯地平和阿托伐他汀)适用于需氨氯地平和阿托伐他汀联合治疗的患者。氨氯地平1、高血压氨氯地平适用于高血压的治疗。可单独应用或与其它抗高血压药物联合应用。2、冠心病(CAD)慢性稳定性心绞痛氨氯地平适用于慢性稳定性心绞痛的对症治疗。可单独应用或与其它抗心绞痛药物联合应用。血管痉挛性心绞痛(Prinzmetal’s 或 变异型心绞痛)氨氯地平适用于确诊或可疑的血管痉挛性心绞痛的治疗。可单独应用也可与其它抗心绞痛药物联合应用。经血管造影证实的冠心病近期经血管造影证实为冠心病,但射血分数≥40%且无心衰的患者,氨氯地平可减少因心绞痛住院的风险以及降低冠状动脉重建术的风险。阿托伐他汀1、 高胆固醇血症原发性高胆固醇血症患者,包括家族性高胆固醇血症(杂合子型)或混合性高脂血症(相当于Fredrickson 分类法的IIa 和IIb 型)患者,如果饮食治疗和其它非药物治疗疗效不满意,应用本品可治疗其总胆固醇升高、低密度脂蛋白胆固醇升高、载脂蛋白B 升高和甘油三酯升高。在纯合子家族性高胆固醇血症患者,阿托伐他汀钙可与其它降脂疗法(如LDL 血浆透析法)合用或单独使用(当无其它治疗手段时),以降低总胆固醇和低密度脂蛋白胆固醇。2、 冠心病:冠心病或冠心病等危症(如:糖尿病,症状性动脉粥样硬化性疾病等)合并高胆固醇血症或混合型血脂异常的患者,本品适用于:降低非致死性心肌梗死的风险、降低致死性和非致死性卒中的风险、降低血管重建术的风险、 降低因充血性心力衰竭而住院的风险、降低心绞痛的风险。
关键词:氨氯地平 阿托伐他汀 高血压 冠心病
Abstract
Amlodipine atorvastatin calcium, indications for up to one ® (amlodipine and atorvastatin) applies for an amlodipine in patients with atorvastatin combination therapy. Amlodipine 1, hypertension amlodipine suitable for the treatment of hypertension. It can be used alone or in combination with other antihypertensive drugs in combination. 2, coronary artery disease (CAD) and chronic stable angina amlodipine apply to the symptomatic treatment of chronic stable angina. It can be used alone or in combination with other antianginal drugs in combination. Vasospastic angina (Prinzmetal's or variant angina) amlodipine suitable for confirmed or suspected vasospastic angina treatment. It can be applied alone or in combination with other anti-anginal drugs. Angiographically documented coronary angiographic Recent coronary heart disease, but without heart failure and ejection fraction ≥40% of patients, amlodipine may reduce the risk of hospitalization for angina and reduce the risk of coronary revascularization. Atorvastatin 1, hypercholesterolemia patients with primary hypercholesterolemia including familial hypercholesterolemia (heterozygous) or combined hyperlipidemia (Fredrickson equivalent taxonomy type IIa and IIb) patient treatment if diet and other non-drug therapy is not satisfied, the application of the product can treat their total cholesterol, LDL cholesterol, apolipoprotein B, and triglycerides increased. In homozygous familial hypercholesterolemia, atorvastatin calcium with other lipid-lowering treatments (eg LDL plasma dialysis) in combination or alone (when no other treatment time) to reduce total cholesterol and low-density lipoprotein protein cholesterol.2, coronary heart disease: coronary heart disease or coronary heart disease risk (such as: diabetes, symptomatic atherosclerotic disease, etc.) in patients with hypercholesterolemia or mixed dyslipidemia, the product is suitable for: reducing nonfatalrisk of myocardial infarction, reduce the risk of fatal and non-fatal stroke, reducing the risk of revascularization, reducing the risk of hospitalization for congestive heart failure, and reduce the risk of angina.
Key Words: Amlodipine Atorvastatin hypertension coronary heart disease
目 录
摘要.............................................................I
ABSTRACT........................................................II
第一章 前言......................................................1
第二章 降血脂药药物种类..................................2
第三章 氨氯地平与阿托伐他汀联合用药的机制................5第四章 复方氨氯地平阿托伐他汀钙片的含量测定方法..........6
第五章 复方氨氯地平阿托伐他汀钙片的含量测定方法的验证....7
5.1 系统适用性试验.......................................7
5.2 线性关系.............................................7
5.3 进样精密度试验.......................................7
5.4 空白辅料干扰试验.....................................8
5.5 回收率试验...........................................8
5.6 溶液放置稳定性试验...................................8
5.7 重复性试验...........................................8
5.8 中间精密度试验.......................................8
5.9 样品含量测定.........................................8
- 实验结果与讨论....................................9
参考文献................................................13
致谢....................................................15
前言
药品名称
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