1. 毕业设计（论文）的内容和要求

一、论文内容： 虾青素即3,3′-二羟基-4,4 ′-二酮基-β,β′-胡萝卜素，为萜烯类不饱和化合物，是一种类胡萝卜素。

天然虾青素是自然界中最强的抗氧化剂之一，可以有效清除细胞内的氧自由基，增强细胞再生能力，维持机体平衡和减少衰老细胞的堆积。

其清除氧自由基的能力是维生素c的6000倍，花青素的700倍。

2. 参考文献

[1] Guerin M, HuntleyM E, Olaizola M. Haematococcus astaxathin: applications for human health and nutrition[J]. Trends in Biotechnolgy. 2003,21(5): 210～216 [2] 张明祥，赵建国.国内外虾青素的研究进展[J].粮食与饲料工业.2002，（1）：26～28。

[3] 欧阳琴．雨生红球藻的培养及其虾青素提取[D]．福州:福州大学硕士论文．2004：18～21. [4] Yuan, J. P.; Gong, X. D.; Chen, F. Separation and identification of astaxanthin esters and chlorophylls in Haematococcus lacustris by HPLC. Biotechnol. Tech. 1996, 10, 655. [5] Crampon, C., Boutin, O., Badens, E., 2011. Supercritical carbon dioxide extraction of molecules of interest from microalgae and seaweeds. Ind. Eng. Chem. Res. 50, 8941-8953. [6]del Valle, J.M., Jimenez, M., Napolitano, P., 2003b. Supercritical carbon dioxide extraction of pelletized Jalapeno peppers. J. Sci. Food Agric. 83, 550 ~ 556 [7] Nobre, B., Marcelo, F., Passos, R., Beirao, L., Palavra, A., Gouveia, L., Mendes, R., 2006.Supercritical carbon dioxide extraction of astaxanthin and other carotenoids from the microalga Haematococcus pluvialis. Eur. Food Res. Technol. 223, 787-790. [8] Ambati, R.R., Phang, S.M., Ravi, S., Aswathanarayana, R.G., 2014. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications #8210; a review. Mar. Drugs 12, 128e152. [9] Sarada R, Tripathi U, Ravishankar G A. Influence of s on astaxanthin production in Haematococcus pluvialis grown under different culture conditions[J]. Process Biochemistry,2002,37:623～627 [10] 王灵昭, 邓家权.微波法提取雨生红球藻中虾青素的工艺研究[J]. 食品研究与开发,2007,28(12):96～100． [11] 周湘池,刘必谦,曾庆国,等.雨生红球藻(Haematococcuspluvialis)破壁方法对虾青素提取率的影响[J].海洋与湖沼,2006,37(5): 424～429 [12] Thana, P., Thana, P., Machmudah, S., Goto, M., Sasaki, M., Pavasant, P., Shotipruk, A.,2008. Response surface methodology to supercritical carbon dioxide extraction of astaxanthin from Haematococcus pluvialis. Bioresour. Technol. 99, 3110-3115. [13]Valderrama, J.O., Perrut, M., 2003. Extraction of astaxantine and phycocyanine from microalgae with supercritical carbon dioxide. J. Chem. Eng. Data 48, 827-830. [14]Yang, Y., Kim, B., Lee, J.Y., 2013. Astaxanthin structure, metabolism, and health benefits. J. Hum. Nutr. Food Sci. 1, 1003. [15]Yuan, J.-P., Peng, J., Yin, K., Wang, J.-H., 2011. Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae. Mol. Nutr. Food Res. 55, 150-165.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 2016.12.23-2017.01.03 选题，与导师讨论题目 2017.01.06 导师下达任务书 2017.01.06-2017.01.13 根据任务书要求，查找相关文献资料，完成开题报告 2017.01.13-05.22 完成试验并提交论文第一稿 2017.05.22-05.28 根据导师意见修改论文第一稿，完成并提交第二稿 2017.05.29-06.2 根据导师意见修改论文第二稿，完成并提交第三稿 2017.06.2-06.14 完成论文的审阅，准备答辩