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毕业论文网 > 任务书 > 化学化工与生命科学类 > 药物制剂 > 正文

ATRP聚合制备亲水性大分子刷修饰的二氧化硅纳米粒子用于癌细胞生物成像任务书

 2020-07-02 10:07  

1. 毕业设计(论文)的内容和要求

(1) 毕业设计包括实验、实验数据处理、毕业论文写作; (2) 毕业设计要求能够了解本领域的研究现状,掌握基本知识点,熟练实验操作。

2. 参考文献

4. 参考文献 (1) Preeti Madhukar Chaudhary, Raghavendra Vasudeva Murthy, Rohan Yadav and Raghavendra Kikkeri* A rationally designed peptidomimetic biosensor for sialic acid on cell surfaces. Chem. Commun., 2015, 51, 8112#8212;8115 (2) Liang Yuan, Xin Hua, Yafeng Wu, Xiaohu Pan, and Songqin Liu* Polymer-Functionalized Silica Nanosphere Labels for Ultrasensitive Detection of Tumor Necrosis Factor-alpha Anal. Chem. 2011, 83, 6800#8211;6809 (3) Remani, P., Nair, R. A., Sreelekha. T. T., Madhavan, J., Vijayakumar, T., Nair, M. K. Differential Expression of Sialic Acid and N-acetylgalactosamine Residues on the Cell Surface of Intestinal Epithelial Cells According to Normal or Metastatic Potential [J]. J. Exp. Clin. Cancer Res. 2000, 19, 519. (4) Gorelik, E., Galili, U., Raz, A. On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis [J]. Cancer Metast. Rev. 2001, 20, 245. (5) Dube, D. H., Bertozzi, C. R. Glycans in cancer and inflammation-potential for therapeutics and diagnostics [J]. Nat. Rev. Drug Discov. 2005, 4, 477. (6) En Han, Lin Ding, and Huangxian Ju, Highly Sensitive Fluorescent Analysis of Dynamic Glycan Expression on Living Cells Using Glyconanoparticles and Functionalized Quantum Dots. Anal. Chem. 2011, 83, 7006#8211;7012

3. 毕业设计(论文)进程安排

2018.1.9-2018.1.15 查阅文献,设计实验方案; 2018.1.15-2018.1.31 二氧化硅纳米离子的制备,大分子刷的接枝; 2018.3.3-2018.3.10 量子点接枝 2018.3.10-2018.3.17 靶标物的接枝 2018.3.17-2018.4.17 荧光纳米粒子的细胞毒性实验。

2018.4.17-2018.5.6 毕业论文写作

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