1. 毕业设计（论文）的内容和要求

现代医疗对疾病的诊断主要依赖于血液化验技术，然而，目前所采用的化验方法需要先后依靠血液的离心分离及生化检验两种相对独立的技术，耗时较长且无法原位获得检验结果。

本项目融合了膜分离及生物传感技术，拟设计和制备一种可实现血液同步分离与检测的新型分离传感膜。

以普鲁士蓝为膜材料，通过中空纤维支撑体孔结构的调控，研究普鲁士蓝在孔内的差异化结晶行为，构建出具有不同纳微结构的分离层及传感层。

2. 参考文献

[1] Ma X.L,Su Y.L,Sun Q.Enhancing the antifouling property of polyethersulfone ultrafiltration membranes through surface adsorption-crosslinking of poly(vinyl alcohol).Journal of Membrane Science 2007,300,71-78. [2] 冯庆玲.生物材料概论[M].北京:清华大学出版社,2009:203. [3] Yung Chang,* Wan-Ju Chang, Yu-Ju Shih, Ta-Chin Wei, and Ging-HoHsiue.Zwitterionic Sulfobetaine-Grafted Poly(vinylidene fluoride) Membrane with Highly Effective Blood Compatibility via Atmospheric Plasma-Induced Surface Copolymerization[J]. ACS applied materials amp; interfaces 2011:1228-37. [4] D. Rana* , T. Matsuura.Surface Modifications for Antifouling Membranes[J].Chemical Review 2010, 110, 2448#8211;2471. [5] Yung Chang , * Yu-Ju Shih , Chia-Jung Lai , Hsiao-Han Kung , and Shaoyi Jiang *. Blood-Inert Surfaces via Ion-Pair Anchoring of Zwitterionic Copolymer Brushes in Human Whole Blood[J]. Advanced Functional Materials 2013:1100-1110. [6] E.M.I. Mala Ekanayake#8727;, D.M.G. Preethichandra, Keiichi Kaneto.Polypyrrole nanotube array sensor for enhanced adsorption of glucose oxidase in glucose biosensors[J]. Biosensors and Bioelectronics 23 (2007) 107#8211;113. [7] Mei-Chan Sin, Sheng-Han Chen and Yung Chang.Hemocompatibility of zwitterionic interfaces and membranes[J]. Polymer Journal 2014, 46, 436#8211;443. [8]Valentini, F ; Fernandez, LG ; Tamburri, E ; Palleschi, G .Single Walled Carbon Nanotubes/polypyrrole-GOx composite films to modify gold microelectrodes for glucose biosensors: Study of the extended linearity[J]. Biosensors and Bioelectronics 2013,43,75-78.

3. 毕业设计（论文）进程安排

2017.01.11-2017.02.20 文献调研，开题报告,拟定实验方案2017.02.20-2017.05.10 开展实验工作，完成数据收集；2017.05.10-2017.06.12 数据整理，撰写论文，准备答辩。