1. 毕业设计（论文）的内容和要求

（1）学会中英文文献的检索方法（2）查阅2，6-二氯苯腈的相关文献，了解国内外的研究进展，以及不同生产方法的优缺点。

（3）培养学生的独立思考的能力，动手操作的能力，（4）和老师进行交流了解大生产化的方法效应，（5）学习色谱和液谱的操作规范，可以独立进行实验的分析。

（6）掌握毕业论文的撰写要求，独立完成毕业论文，加深对该方向的了解。

2. 参考文献

[1] Natte K, Jagadeesh R V, Sharif M, et al. Synthesis of nitriles from amines using nanoscale Co#172;3O4-based catalysts via sustainable aerobic oxidation[J]. Organic biomolecular chemistry, 2016, 14(13): 3356-3359. [2] Men#233;ndez-Rodr#237;guez L, Tom#225;s-Mendivil E, Francos J, et al. Palladium (II) complexes with a phosphino-oxime ligand: synthesis, structure and applications to the catalytic rearrangement and dehydration of aldoximes[J]. Catalysis Science Technology, 2015, 5(7): 3754-3761. [3] Augustine J K, Bombrun A, Atta R N. A Practical and Cost-Efficient, One-Pot Conversion of Aldehydes into Nitriles Mediated by ”Activated DMSO#8217;[J]. Synlett, 2011, 2011(15): 2223-2227. [4] Supsana P, Liaskopoulos T, Tsoungas P G, et al. DMF-catalysed thermal dehydration of aldoximes: a convenient access to functionalized aliphatic and aromatic nitriles[J]. Synlett, 2007, 2007(17): 2671-2674. [5] Sharghi H, Saravi M H. An efficient solvent free and one-pot conversion of aldehydes into nitriles using NH2OH. HCl/CH3COCl/charcoal system[J]. Journal of the Iranian Chemical Society, 2004, 1(1): 28-32. [6] Iranpoor N, Zeynizadeh B. Efficient dehydration of aldoximes to nitriles with TiCl3 (OTf)[J]. Synthetic communications, 1999, 29(16): 2747-2752. [7] Nakajima N, Saito M, Ubukata M. Activated dimethyl sulfoxide dehydration of amide and its application to one-pot preparation of benzyl-type perfluoroimidates[J]. Tetrahedron, 2002, 58(18): 3561-3577. [8] Telvekar V N, Rane R A, Namjoshi T V. Novel System for the Synthesis of Nitriles from Aldehydes Using Aqueous Ammonia and [Bis(Trifluoroacetoxy)iodo] benzene[J]. Synthetic Communications#174;, 2010, 40(4): 494-497. [9] Masjed S M, Akhlaghinia B, Zarghani M, et al. Direct Synthesis of Nitriles from Aldehydes and Hydroxylamine Hydrochloride Catalyzed by a HAP@ AEPH2-SO3H Nanocatalyst[J]. Australian Journal of Chemistry, 2017, 70(1): 33-43.

3. 毕业设计（论文）进程安排

2017.3.1-2017.3.10 查阅收集文献资料，了解课题背景，完成开题报告的撰写；为实验作准备工作。

2017.3.11-2017.3.31 制备2，6-二氯苯腈，并学会使用气相色谱、液相色谱分析；对温度、溶剂量、脱水剂做单因素实验； 2017.4.1-2017.5.15 对温度、溶剂量、脱水剂做单因素实验；并且撰写中期自查表； 2017.5.16-2017.6.1 梳理实验思路及数据，为撰写论文作准备； 2017.6.1-2017.6.11 撰写论文，准备论文答辩。